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Ladyburn 1974 is a rare and powerful hybrid cannabis strain known for its strong effects, unique flavor profile, and impressive therapeutic benefits. This strain was developed by Green House Seeds, one of the most well-known seed banks in the cannabis industry. With its genetic lineage tracing back to Jack Herer and Ice, Ladyburn 1974 is a balanced hybrid that delivers a mix of cerebral stimulation and body relaxation, making it a popular strain among users for medical and recreational purposes.
This guide provides an in-depth look at the genetic background, appearance, aroma, THC and CBD content, medical benefits, recreational uses, growing conditions, and scientific insights related to Ladyburn 1974.
1. Genetic Background
Ladyburn 1974 is a hybrid strain with a genetic composition that leans slightly toward the Indica side, making it approximately 60% Indica and 40% Sativa. It is a hybrid of two renowned strains:
- Jack Herer – A Sativa-dominant strain known for its uplifting cerebral effects, creativity-enhancing properties, and earthy-pine aroma.
- Ice – A potent hybrid recognized for its high resin production, sweet-spicy aroma, and deeply relaxing effects.
The combination of these two parent strains results in a well-balanced hybrid that offers both mental stimulation and full-body relaxation. Ladyburn 1974 is often used by those seeking a strain that provides therapeutic benefits without extreme sedation.
2. Appearance, Aroma, and Flavor Profile
Appearance
Ladyburn 1974 is a visually striking strain, characterized by its dense, resin-covered buds. The flowers are typically large and compact, displaying a vibrant mix of deep green and orange hues. The buds are often coated in a thick layer of white trichomes, signifying their high potency.

Aroma
The aroma of Ladyburn 1974 is complex and unique, featuring a blend of citrus, spice, and earthiness. The primary scent notes include:
- Citrus (Lemon, Orange) – A bright and zesty aroma, inherited from Jack Herer.
- Pine and Earth – A classic cannabis scent that adds depth to the overall fragrance.
- Spicy and Herbal Undertones – Subtle hints of spice and herbal notes, likely derived from the Ice parent strain.
Flavor
When consumed, Ladyburn 1974 offers a smooth and flavorful smoking or vaping experience. The taste profile mirrors its aroma, delivering a delightful combination of flavors:
- A citrusy, tangy inhale with hints of lemon and orange.
- A spicy, earthy exhale with undertones of pine and herbal sweetness.
- A lingering aftertaste that combines both citrus zest and a slightly peppery kick.
3. THC and CBD Content
Ladyburn 1974 is a high-THC strain, with levels typically ranging between 19% and 22%. This makes it a potent choice for users who require strong effects, whether for medical or recreational purposes.

The CBD content in Ladyburn 1974 is relatively low, generally below 1%, meaning that its therapeutic properties are primarily driven by THC and other cannabinoids rather than CBD.
4. Medical Uses of Ladyburn 1974 Cannabis Strain
Ladyburn 1974 is a hybrid strain (60% Indica, 40% Sativa) with a high THC content (19-22%) and low CBD (<1%). Due to its unique cannabinoid and terpene profile, it offers multiple therapeutic benefits. This section provides a scientific breakdown of its medical uses, mechanisms of action, and how it interacts with the human body.
Mechanism of Action: How Ladyburn 1974 Works in the Body
The therapeutic effects of Ladyburn 1974 are driven by its cannabinoids and terpenes, which interact with the endocannabinoid system (ECS).
A. Cannabinoids in Ladyburn 1974
- THC (Δ9-Tetrahydrocannabinol) – 19-22%
- Binds to central nervous system and brain CB1 receptors.
- Produces euphoric, analgesic, and anti-inflammatory effects.
- Modulates dopamine release, enhancing mood stabilization.
- CBD (Cannabidiol) – <1%
- Indirectly influences CB1 and CB2 receptors.
- Has neuroprotective, anxiolytic, and anti-inflammatory properties.
- Modulates the psychoactive effects of THC.
B. Terpenes in Ladyburn 1974
- Limonene: Antidepressant, anxiolytic (stress reduction).
- Myrcene: Sedative, muscle relaxant, anti-inflammatory.
- Caryophyllene: Anti-inflammatory, pain relief.
- Pinene: Bronchodilator, cognitive enhancer.
The synergistic effect of these compounds (known as the entourage effect) enhances the strain’s medical benefits.
Pain Management
A. Chronic Pain
Ladyburn 1974 has strong analgesic (pain-relieving) properties due to its high THC content.
- THC binds to CB1 receptors in the central nervous system, reducing pain perception.
- Terpenes like caryophyllene and myrcene act on TRPV1 receptors, reducing inflammation and discomfort.
Effective for:
- Neuropathic pain (nerve damage, sciatica, multiple sclerosis).
- Musculoskeletal pain (arthritis, fibromyalgia, lower back pain).
- Cancer-related pain.
B. Migraine Relief
- THC modulates serotonin levels, which influence migraines.
- Pinene and Limonene improve oxygen flow to the brain, reducing headache intensity.
- Caryophyllene’s anti-inflammatory properties relieve vascular inflammation linked to migraines.
Recommended usage:
- Low-to-moderate doses prevent overstimulation of CB1 receptors, which can worsen headaches.
- Vaporization preferred for rapid onset of relief.
Anxiety and Stress Reduction
A. Generalized Anxiety Disorder (GAD)
- THC, at moderate doses, reduces excessive neuronal activity, which helps in calming the nervous system.
- Limonene has anxiolytic properties, supporting mood stabilization.
- Myrcene promotes relaxation by enhancing GABA receptor activity.
Best for:
- Social anxiety disorder.
- General stress relief.
- PTSD-related anxiety.
Caution: High doses of THC may induce paranoia in sensitive users. Controlled dosing is recommended.
B. Insomnia and Sleep Disorders
- Myrcene and caryophyllene contribute to deep muscle relaxation.
- THC reduces REM sleep, beneficial for PTSD patients who experience nightmares.
- Helps users fall asleep faster and improves sleep quality.
Recommended:
- Evening use, 1-2 hours before bedtime.
- Avoid overuse to prevent next-day grogginess.
Depression and Mood Disorders
Ladyburn 1974 has antidepressant-like properties due to its interaction with dopamine and serotonin pathways.
- Limonene boosts serotonin levels, improving mood.
- THC activates CB1 receptors, increasing dopamine release, promoting happiness and motivation.
- Caryophyllene modulates the HPA axis, helping to stabilize stress response.
Effective for:
- Mild to moderate depression.
- Seasonal Affective Disorder (SAD).
- Bipolar disorder (depressive phase, not mania).
Caution: Not recommended for bipolar mania or individuals prone to psychosis.
Appetite Stimulation (For Cancer, HIV/AIDS, Anorexia)
THC in Ladyburn 1974 stimulates appetite by acting on CB1 receptors in the hypothalamus, enhancing ghrelin release (hunger hormone).
Beneficial for:
- Cancer patients undergoing chemotherapy (counteracts nausea, enhances appetite).
- HIV/AIDS patients (prevents wasting syndrome).
- Anorexia nervosa (increases food intake, reduces anxiety around eating).
Caution: Overuse may lead to excessive calorie intake.
Neurological and Neuroprotective Benefits
A. Multiple Sclerosis (MS)
- THC reduces muscle spasms via CB1 receptor activation.
- Caryophyllene and myrcene have anti-inflammatory effects that reduce nerve pain.
- Improves mobility and reduces tremors in MS patients.
Recommended:
- Microdosing (5-10 mg THC) to prevent cognitive impairment.
B. Alzheimer’s and Cognitive Decline
- Pinene acts as an acetylcholinesterase inhibitor, helping memory retention.
- THC reduces amyloid plaque accumulation, which is linked to Alzheimer’s progression.
Potential benefits:
- Delays cognitive decline.
- Supports memory retention in early Alzheimer’s.
Anti-Inflammatory and Autoimmune Support
Ladyburn 1974’s anti-inflammatory cannabinoids and terpenes make it useful for treating autoimmune disorders.
Effective for:
- Rheumatoid arthritis – Reduces joint inflammation.
- Crohn’s disease and IBS – Eases gut inflammation.
- Lupus – Modulates the immune response.
Nausea and Chemotherapy-Induced Side Effects
A. Anti-Emetic Properties
- THC acts on CB1 receptors in the brainstem, blocking nausea signals.
- Limonene and pinene provide additional relief by soothing gastric motility.
Recommended for:
- Chemotherapy patients experiencing nausea.
- Post-surgical nausea relief.
Caution: Higher THC doses can cause dizziness in sensitive users.
Potential Side Effects and Risk Factors
While Ladyburn 1974 offers significant medical benefits, it also has side effects, especially when taken in high doses.
A. Short-Term Side Effects
- Dry Mouth & Eyes – Due to reduced saliva and tear production.
- Dizziness & Lightheadedness – Linked to THC-induced blood pressure drops.
- Paranoia & Anxiety – Excess THC can overstimulate the amygdala.
- Short-Term Memory Impairment – More common in high doses.
B. Long-Term Considerations
- THC Tolerance: Frequent use may lead to tolerance buildup.
- Cognitive Effects: High doses in adolescents may alter brain development.
- Respiratory Issues: If smoked, increases risk of bronchitis and lung irritation.
Risk Reduction Strategies:
- Microdosing (2.5-5 mg THC).
- Using vaporizers to avoid respiratory issues.
- Cycling usage to prevent tolerance buildup.
5. Recreational Uses of Ladyburn 1974 Cannabis Strain
Ladyburn 1974 is highly favored among recreational users due to its balanced effects, making it appropriate for a range of social situations and activities.
Euphoria and Creativity
The cerebral effects of this strain can enhance creativity and artistic expression. Users often report feeling inspired and mentally stimulated, making it an excellent strain for creative pursuits such as painting, writing, or music.
Relaxation and Stress Relief
Despite its uplifting properties, Ladyburn 1974 also offers deep body relaxation, making it a great strain to relax after a tough day.
Social Interactions
Ladyburn 1974 can enhance social interactions by reducing inhibitions and promoting a relaxed, talkative state.
Evening and Nighttime Use
Due to its balanced effects, this strain is ideal for late afternoon or evening use, as it provides relaxation without immediate sedation.
6. Growing Ladyburn 1974 Cannabis Strain
Ladyburn 1974 is a relatively easy strain to cultivate, making it a good choice for both beginner and experienced growers.
Growing Conditions
- Indoor Cultivation:
- Thrives in a controlled environment with consistent temperatures (68-78°F or 20-26°C).
- Requires proper humidity management to prevent mold and mildew.
- Flowering period of approximately 9 weeks.
- Outdoor Cultivation:
- Best grown in Mediterranean-like climates.
- Can reach impressive heights with proper sunlight exposure.
- Harvest period: Early to mid-October.
Yield and Harvesting
- Indoor Yield: 500-700 grams per square meter.
- Outdoor Yield: Up to 1000 grams per plant.
- High resin production makes it an excellent strain for extracts and concentrates.

7. Scientific Insights on Ladyburn 1974
Ladyburn 1974’s effects are largely influenced by its terpene profile, which includes:
- Limonene: Has uplifting effects and a citrus scent.
- Myrcene: Offers relaxing, sedative qualities.
- Caryophyllene: Known for anti-inflammatory and pain-relieving benefits.
The interaction between THC and these terpenes contributes to the strain’s unique balance of effects, making it a versatile choice for both medical and recreational users.
8. Side Effects of Ladyburn 1974
Like most cannabis strains, Ladyburn 1974 has a few potential side effects:
- Dry Mouth and Eyes – Common and can be managed with hydration and eye drops.
- Dizziness – May occur in high doses, especially for beginners.
- Paranoia or Anxiety – Rare but possible at high THC doses.
Conclusion
Ladyburn 1974 is a well-balanced hybrid with a rich genetic background, potent effects, and a complex aroma. It is ideal for those seeking pain relief, mood enhancement, and relaxation without excessive sedation. With a relatively easy cultivation process and high yield potential, it is a fantastic choice for both medical patients and recreational users alike.
For a complete directory of cultivars, visit our Cannabis Strain Reviews.